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Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety.

Abstract：

:Two new series of Mannich bases, namely, 1-(morpholino)methyl-3-(4-methylthiobenzyl)-4-(substituted arylidene)amino-1,2,4-triazol-5-thiones 3 and 1-(N-methylpiperazino)methyl-3-(4-methylthiobenzyl)-4-(substituted arylidene)amino-1,2,4-triazol-5-thiones 4 have been synthesized by a three-component Mannich reaction (MCR) involving 3-(4-methylthiobenzyl)-4-(substituted arylidene)amino-5-mercapto-1,2,4-triazoles 2, formaldehyde and morpholine/N-methylpiperazine. The newly synthesized compounds were well characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ashok M,Holla BS,Poojary B

doi

10.1016/j.ejmech.2007.01.015

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

1095-101

issue

8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00053-0

journal_volume

42

pub_type

杂志文章

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