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Bioactive fused heterocycles: Nucleoside analogs with an additional ring.

Abstract：

:The following mini-review summarizes the basic literature data regarding synthesis, biological activity, structure-activity relationship, and discussion of the mechanisms of action of two major classes of nucleoside analogs with fused heterocyclic rings: (i) the ethenonucleosides and their related derivatives of the 5,9-dihydro-3-glycosyl-6-alkyl-9-oxo-5H-imidazo[1,2-a]purine type; (ii) the bicyclic nucleosides of 6-alkyl-2,3-dihydrofurano[2,3-d]-pyrimidin-2(3H)-one and 6-alkyl-2,3-dihydropyrrolo[2,3-d]-pyrimidin-2(3H,7H)-one.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Jahnz-Wechmann Z,Framski G,Januszczyk P,Boryski J

doi

10.1016/j.ejmech.2014.12.026

subject

Has Abstract

pub_date

2015-06-05 00:00:00

pages

388-96

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)01135-0

journal_volume

97

pub_type

杂志文章,评审

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