Design, synthesis and antifungal activities of novel pyrrole alkaloid analogs.

Abstract:

:A series of novel analogs of pyrrole alkaloid were designed and synthesized by a facile method and their structures were characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS). The structure of compound 2a was identified by 2D NMR including heteronuclear multiple-quantum coherence (HMQC), heteronuclear multiple-bond correlation (HMBC) and H-H correlation spectrometry (H-H COSY) spectra. Their antifungal activities against five fungi were evaluated, and the results indicated that some of the title compounds showed moderate fungicidal activities in vitro against Alternaria solani, Cercospora arachidicola, Fusarium omysporum, Gibberella zeae and Physalospora piricola at the dosage of 50 μg mL(-1). Compound 2a and 3a exhibited good activities against P. piricola at low dosage.

journal_name

Eur J Med Chem

authors

Wang MZ,Xu H,Liu TW,Feng Q,Yu SJ,Wang SH,Li ZM

doi

10.1016/j.ejmech.2011.01.031

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1463-72

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00053-5

journal_volume

46

pub_type

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