Abstract:
:A series of novel analogs of pyrrole alkaloid were designed and synthesized by a facile method and their structures were characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS). The structure of compound 2a was identified by 2D NMR including heteronuclear multiple-quantum coherence (HMQC), heteronuclear multiple-bond correlation (HMBC) and H-H correlation spectrometry (H-H COSY) spectra. Their antifungal activities against five fungi were evaluated, and the results indicated that some of the title compounds showed moderate fungicidal activities in vitro against Alternaria solani, Cercospora arachidicola, Fusarium omysporum, Gibberella zeae and Physalospora piricola at the dosage of 50 μg mL(-1). Compound 2a and 3a exhibited good activities against P. piricola at low dosage.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Wang MZ,Xu H,Liu TW,Feng Q,Yu SJ,Wang SH,Li ZMdoi
10.1016/j.ejmech.2011.01.031subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1463-72issue
5eissn
0223-5234issn
1768-3254pii
S0223-5234(11)00053-5journal_volume
46pub_type
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