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Cyclocondensation reaction of heterocyclic carbonyl compounds. Part XIII: synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines.

Abstract：

:A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines have been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines. Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selectively active against lung adenocarcinoma cell line A549.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Gucký T,Frysová I,Slouka J,Hajdúch M,Dzubák P

doi

10.1016/j.ejmech.2008.05.026

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

891-900

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00289-4

journal_volume

44

pub_type

杂志文章

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