Abstract:
:The two new mononuclear complexes were prepared by reacting symmetric Schiff base, containing pyrimidine rings and the metal chlorides of Pd(II) and Pt(II) in methanol. The mononuclear structure of the complexes was confirmed on the basis of elemental analyses, magnetic susceptibility, IR, UV-Vis, NMR, DTA/TGA and API-ES mass spectral data. The interaction of these metal complexes with fish sperm double-stranded DNA (dsDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse (DP) voltammetry by using renewable pencil graphite electrode was employed to monitor the DNA interaction at the surface or in solution. The results indicate that Pd(II) and (Pt) complexes with Schiff base ligand having pyrimidine rings strongly interacted with DNA.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Sönmez M,Celebi M,Yardim Y,Sentürk Zdoi
10.1016/j.ejmech.2010.06.016subject
Has Abstractpub_date
2010-09-01 00:00:00pages
4215-20issue
9eissn
0223-5234issn
1768-3254pii
S0223-5234(10)00460-5journal_volume
45pub_type
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