当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives.

Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives.

Abstract：

:Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyelocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

He L,Chang HX,Chou TC,Savaraj N,Cheng CC

doi

10.1016/s0223-5234(02)01420-4

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

101-7

issue

1

eissn

0223-5234

issn

1768-3254

pii

S0223523402014204

journal_volume

38

pub_type

杂志文章

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