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Comparative study on antioxidant capacity of flavonoids and their inhibitory effects on oleic acid-induced hepatic steatosis in vitro.

Abstract：

:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and its incidence is rising worldwide. We compared the antioxidant capacity of seventeen flavonoids with their inhibitory effects on oleic acid-induced triglyceride (TG) over-accumulation in HepG2 cells. The results showed significant correlations (P < 0.01) between the inhibition of intracellular TG levels and the suppression effects on reactive oxygen species. Nevertheless, the radical-reducing activities of flavonoids assessed by chemical assays (cyclic voltammetry and Folin-Ciocalteu reagent assay) were poorly correlated with their intracellular TG inhibitory effects. The relationships between structural properties of flavonoids and their inhibitory effects on TG over-accumulation were discussed.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Zhang D,Xie L,Jia G,Cai S,Ji B,Liu Y,Wu W,Zhou F,Wang A,Chu L,Wei Y,Liu J,Gao F

doi

10.1016/j.ejmech.2011.07.031

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

4548-58

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00544-7

journal_volume

46

pub_type

杂志文章

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