Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives.

Abstract:

:Innate immunity is the front line of self-defense against infectious microorganisms. In mammals, innate immunity interacts with adaptive immunity and plays a key role in regulating the immune response. Therefore, innate immunity is a good pharmaceutical target for the development of immune regulators. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a cyclopentanediol-type compound 1 as an immunosuppressor. In this study, we synthesized and evaluated 1 and its derivatives. Several methylamide- or phenylamide-containing derivatives showed effects that were 20-25 times more potent than those of 1.

journal_name

Eur J Med Chem

authors

Kikuchi H,Okazaki K,Sekiya M,Uryu Y,Ueda K,Katou Y,Kurata S,Oshima Y

doi

10.1016/j.ejmech.2011.01.049

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

1263-73

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00071-7

journal_volume

46

pub_type

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