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Recent advances in HER2 positive breast cancer epigenetics: Susceptibility and therapeutic strategies.

Abstract：

:HER2 amplification/overexpression accounts for aggressive clinical features of HER2 positive breast cancer. Epigenetic changes including DNA methylation, histone modifications and ncRNAs/miRNAs are associated with regulation of DNA chromatin and specifically, gene transcription. Hence, these produce eminent effects upon proto-oncogenes, tumor-suppressors and key cancer-regulatory signaling pathways. Understanding of epigenomic regulation of HER2 overexpression and signaling may help uncover the unmatchable physiology of HER2 gene/protein. Moreover, this may also aid in resolving the major issue of resistance-development towards HER2 targeted agents (trastuzumab and lapatinib), since epigenetic alterations are important therapeutic markers and modulate the response towards HER2 targeted therapy. Therefore, in this review the information regarding various epigenetic markers implicated in HER2 positive breast cancer susceptibility and therapeutic-strategies has been compiled.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Singla H,Ludhiadch A,Kaur RP,Chander H,Kumar V,Munshi A

doi

10.1016/j.ejmech.2017.07.075

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

316-327

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(17)30597-4

journal_volume

142

pub_type

杂志文章,评审

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