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Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance.

Abstract：

:Gynaecological disorders, such as cervical, ovarian, and endometrial cancers are the second most prevalent cancer types in women worldwide. Therapeutic approaches for gynaecological cancers involve chemotherapy, radiation, and surgery. However, lifespan is not improved, and novel medications are required. Among various phytochemicals, berberine, a well-known natural product, has been shown to be a promising cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of berberine have been investigated in the several experiments against numerous diseases. Here, we aimed to provide a literature review from available published investigations showing the anticancer effects of berberine and its various synthetic analogues against gynaecological disorders, including cervical, ovarian, and endometrial cancers. In conclusion, berberine has been found to efficiently inhibit viability, proliferation, and migration of cancer cells, mainly, via induction of apoptosis by both mitochondrial dependent and -independent pathways. Additionally, structural modification of berberine showed that berberine analogues can improve its antitumor effects against gynaecological cancers.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Mortazavi H,Nikfar B,Esmaeili SA,Rafieenia F,Saburi E,Chaichian S,Heidari Gorji MA,Momtazi-Borojeni AA

doi

10.1016/j.ejmech.2019.111951

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

111951

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(19)31103-1

journal_volume

187

pub_type

杂志文章,评审

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