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Synthesis, antiarrhythmic and anticoagulant activities of novel thiazolo derivatives from methyl 2-(thiazol-2-ylcarbamoyl)acetate.

Abstract：

:A series of novel thiazolo derivatives were synthesized by initial condensation of methyl 2-(thiazol-2-ylcarbamoyl)acetate with phenyl isothiocyanate and further reactions using different organic reagents. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, EIMS spectral data and elemental analysis. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). All the compounds were screened for their antiarrhythmic and anticoagulant activities and they showed high antiarrhythmic activity compared with procaine amide and lidocaine as positive controls. The detailed synthesis, spectroscopic data, LD(50) and pharmacological activities of the synthesized compounds were reported.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Amr Ael-G,Sabrry NM,Abdalla MM,Abdel-Wahab BF

doi

10.1016/j.ejmech.2008.05.004

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

725-35

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00267-5

journal_volume

44

pub_type

杂志文章

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