当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report.

Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report.

Abstract：

:α-Santonin derived new series of 1,2,3-triazoles synthesized through Azide-Alkyne Huisgen 1,3-dipolar cycloaddition reaction between substituted aryl azide and a propargylated α-desmotrosantonin were bio-evaluated for their diminutive effect on ConA induced T-cell and LPS induced B-cell proliferation. Interestingly, most of the synthesized compounds showed better immunosuppressant activity than α-santonin. Triazole derivatives 9, 10, 17, 18, 29, and 30 displayed significant diminutive effect on cell proliferation. Compounds 12 and 13 were found selective against ConA T-cell proliferation exhibiting >90% inhibition at 1 × 10(-6) M concentration. The present study resulted in identification of several triazole derivatives as effective immunosuppressive agents.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Chinthakindi PK,Sangwan PL,Farooq S,Aleti RR,Kaul A,Saxena AK,Murthy YL,Vishwakarma RA,Koul S

doi

10.1016/j.ejmech.2012.12.018

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

365-75

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(12)00740-4

journal_volume

60

pub_type

杂志文章

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