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Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents.

Abstract：

:A series of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives have been synthesized. The structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass spectral data and elemental analyses. Compounds were evaluated for their anti-inflammatory and analgesic activity as well as gastric ulcerogenic effects. Derivatives 4a, 4b and 4c exhibited moderate to good anti-inflammatory and analgesic activity in carrageenan-induced rat paw edema and acetic acid-induced writhing in mice, respectively, with low ulcerogenicity compared with the standard drug indomethacin.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Gaba M,Singh D,Singh S,Sharma V,Gaba P

doi

10.1016/j.ejmech.2010.01.067

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

2245-9

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00112-1

journal_volume

45

pub_type

杂志文章

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