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Design, synthesis, and antibacterial activity of novel Schiff base derivatives of quinazolin-4(3H)-one.

Abstract：

:Novel imine derivatives of quinazolin-4(3H)-one were designed and synthesized by using aminoethyl moieties to increase the amine bridge of quinazolin-4(3H)-one amine and then introducing various aromatic aldehydes. The target compounds were characterized by proton nuclear magnetic resonance spectroscopy ((1)H NMR), carbon nuclear magnetic resonance spectroscopy ((13)C NMR), mass spectrometry (MS), infrared spectroscopy (IR), elemental analysis, and X-ray diffraction crystallography. Bioassay results indicated that some of the compounds showed good to excellent antibacterial activities against tobacco bacterial wilt and tomato bacterial wilt. The 50% effective concentrations (EC50) of the compounds against tobacco and tomato bacterial wilts ranged from 63.73 μg/mL to 201.52 μg/mL and 38.64 μg/mL to 81.39 μg/mL, respectively, which are lower than that the positive control thiodiazole copper (216.70 and 99.80 μg/mL). These results indicated that novel Schiff base derivatives containing the 4(3H)-quinazolinone moiety can effectively control tobacco and tomato bacterial wilts.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Wang X,Yin J,Shi L,Zhang G,Song B

doi

10.1016/j.ejmech.2014.02.053

subject

Has Abstract

pub_date

2014-04-22 00:00:00

pages

65-74

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00183-4

journal_volume

77

pub_type

杂志文章

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