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Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening.

Abstract：

:Various 3-[4-(substituted phenyl)-1,3-thiazol-2-ylamino]-4-(substituted phenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones (7a-t) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity. Thiazole and triazole moieties being anticonvulsants were clubbed together to get the titled compounds and their in vivo anticonvulsant screening were performed by two most adopted seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). Two compounds 7d and 7f showed significant anticonvulsant activity in both the screens with ED(50) values 23.9 mg/kg and 13.4 mg/kg respectively in MES screen and 178.6 mg/kg and 81.6 mg/kg respectively in scPTZ test. They displayed a wide margin of safety with Protective index (PI), median hypnotic dose (HD(50)) and median lethal dose (LD(50)) much higher than the standard drugs.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Siddiqui N,Ahsan W

doi

10.1016/j.ejmech.2009.12.062

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1536-43

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00029-2

journal_volume

45

pub_type

杂志文章

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