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Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety.

Abstract：

:Enaminonitrile 2 was used as key intermediate for the synthesis of polyfunctionally substituted heterocycles (e.g. pyrazoles, isoxazole, pyrimidines, thiazolo[3,2-a]pyrimidine, tetrazolo[1,5-a]pyrimidine, pyrido[1,2-a]pyrimidine, 1,5-benzodiazepine, and pyrazolo[1,5-a]pyrimidine) incorporating benzothiazole moiety via its reactions with some N-nucleophiles. The newly synthesized compounds were characterized by IR, (1)H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Bondock S,Fadaly W,Metwally MA

doi

10.1016/j.ejmech.2009.07.024

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

4813-8

issue

12

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00410-3

journal_volume

44

pub_type

杂志文章

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