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Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities.

Abstract：

:New alkyl 2,6,6-(2,7,7)-trimethyl-4-(2-fluoro-3-chloro-5-trifluoromethylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and 9-(3-chloro-2-fluoro-5-trifluoromethylphenyl)-6,6(7,7)-dimethyl-6,7-dihydrofuro[3,4-b]quinoline-1,8-diones have been synthesised and their calcium antagonistic activities on isolated rabbit sigmoid colon have been investigated and compared with Nifedipine. The investigation examined the influence of ester groups in the 3-position of the HHQ ring and the 2-methoxyethyl analogs were found to be the most active derivatives.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Bülbül B,Oztürk GS,Vural M,Simşek R,Sarioğlu Y,Linden A,Ulgen M,Safak C

doi

10.1016/j.ejmech.2008.10.008

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

2052-8

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00501-1

journal_volume

44

pub_type

杂志文章

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