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Model for high-throughput screening of drug immunotoxicity--study of the anti-microbial G1 over peritoneal macrophages using flow cytometry.

Abstract：

:Quantitative Structure-Activity (mt-QSAR) techniques may become an important tool for prediction of cytotoxicity and High-throughput Screening (HTS) of drugs to rationalize drug discovery process. In this work, we train and validate by the first time mt-QSAR model using TOPS-MODE approach to calculate drug molecular descriptors and Linear Discriminant Analysis (LDA) function. This model correctly classifies 8258 out of 9000 (Accuracy = 91.76%) multiplexing assay endpoints of 7903 drugs (including both train and validation series). Each endpoint correspond to one out of 1418 assays, 36 molecular and cellular targets, 46 standard type measures, in two possible organisms (human and mouse). After that, we determined experimentally, by the first time, the values of EC50 = 21.58 μg/mL and Cytotoxicity = 23.6% for the anti-microbial/anti-parasite drug G1 over Balb/C mouse peritoneal macrophages using flow cytometry. In addition, the model predicts for G1 only 7 positive endpoints out 1251 cytotoxicity assays (0.56% of probability of cytotoxicity in multiple assays). The results obtained complement the toxicological studies of this important drug. This work adds a new tool to the existing pool of few methods useful for multi-target HTS of ChEMBL and other libraries of compounds towards drug discovery.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Tenorio-Borroto E,Peñuelas-Rivas CG,Vásquez-Chagoyán JC,Castañedo N,Prado-Prado FJ,García-Mera X,González-Díaz H

doi

10.1016/j.ejmech.2013.08.035

subject

Has Abstract

pub_date

2014-01-24 00:00:00

pages

206-20

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00552-7

journal_volume

72

pub_type

杂志文章

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