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Synthesis, biological evaluation and molecular docking studies of some pyrimidine derivatives.

Abstract：

:Some novel pyrimidine-5-carbonitrile derivatives bearing various substituent have been synthesized. The structures of target compounds were confirmed by elemental analysis and spectral data. Some selected members of the newly synthesized compounds were investigated for their cytotoxic potency against certain human tumor cell lines. Five representative active anticancer compounds 6a, 6c, 6d, 17a and 18a were subjected to docking using MOE program on the 3D structure of two enzymes, namely; thymidylate synthase and dihydrofolate reductase. The antimicrobial activities of the synthesized compounds were tested against Staphylococcus aureus, Pseudomonas aeruginosa, Shigella flexneri and Candida albicans. Compounds 2c, 7a and 9c showed broad spectrum antimicrobial activity.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Fargualy AM,Habib NS,Ismail KA,Hassan AM,Sarg MT

doi

10.1016/j.ejmech.2013.05.028

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

276-95

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00337-1

journal_volume

66

pub_type

杂志文章

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