Abstract:
:Several diarylamide compounds have been highlighted as potential anticancer agents. Among them, imatinib, dasatinib, and nilotinib have been marketed for treatment of chronic myeloid leukemia (CML). CML is a cancer type that originates in specific cells in bone marrow and is considered as life-threating disease. Imatinib is the first generation of tyrosine kinase inhibitor (TKI) to be approved for treatment of CML. Second generation drugs, dasatinib and nilotinib, were introduced for patients that are resistant or intolerant to imatinib therapy. Second generation drugs induce faster responses with fewer side effects when compared to imatinib. In this literature review, we reviewed recent advances of diarylamide anticancer agents, including first and second generation drugs treating CML and their other uses, in addition to other compounds that are still in preclinical phases. This review focuses on the reports published in the literature from 2010 to 2019.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Abduelkarem AR,Anbar HS,Zaraei SO,Alfar AA,Al-Zoubi OS,Abdelkarem EG,El-Gamal MIdoi
10.1016/j.ejmech.2019.112029subject
Has Abstractpub_date
2020-02-15 00:00:00pages
112029eissn
0223-5234issn
1768-3254pii
S0223-5234(19)31187-0journal_volume
188pub_type
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