当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Unveiling the mode of action of antibacterial labdane diterpenes from Alpinia nigra (Gaertn.) B. L. Burtt seeds.

Unveiling the mode of action of antibacterial labdane diterpenes from Alpinia nigra (Gaertn.) B. L. Burtt seeds.

Abstract：

:The labdane diterpene, (E)-labda-8(17), 12-diene-15, 16-dial (compound A) and its epoxide analogue, (E)-8β, 17-Epoxylabd-12-ene-15, 16-dial (compound B) were isolated from the seeds of Alpinia nigra for the first time. The antibacterial activities of both compounds were evaluated against three Gram-positive and four Gram-negative bacteria, and flow cytometric analysis revealed that these compounds caused significant damage to the bacterial cell membranes. Further, field emission scanning electron microscope imaging and cell leakage analysis confirmed that the labdane diterpenes were responsible for bacterial cell membrane damage and disintegration. Our findings provide new insight into the broad-spectrum effects of two natural labdane diterpenes that may be useful in the future development of herbal antibiotic products.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ghosh S,Indukuri K,Bondalapati S,Saikia AK,Rangan L

doi

10.1016/j.ejmech.2013.05.034

keywords:

["Alpinia nigra","Antibacterial activity","Flow cytometry","Labdane diterpene","Zingiberaceae"]

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

101-5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00343-7

journal_volume

66

pub_type

杂志文章

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