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Lipid lowering agents of natural origin: An account of some promising chemotypes.

Abstract：

:The role of natural products in the drug development and discovery has been phenomenal. There has been an enormous interest in exploring all possible natural sources to identify structures exhibiting pronounced hypolipidemic activity albeit with no toxicity. The present review describes the profile of some interesting naturally occurring compounds and their derivatives as potential hypolipidemic agents. Some of the interesting natural chemotypes that can control the increased levels of plasma lipids and discussed in this review are compactin, lovastatin, gugglesterone, berberine, lupeol, phytol, polyprenol, aegeline, 4-hydroxyisoleucine, α-asarone, resveratrol, esculeoside A, swertiamarin, rutin, saucerneol B, curcumin and a clerodane diterpene.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Singh SP,Sashidhara KV

doi

10.1016/j.ejmech.2017.09.020

subject

Has Abstract

pub_date

2017-11-10 00:00:00

pages

331-348

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(17)30734-1

journal_volume

140

pub_type

杂志文章,评审

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