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Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents.

Abstract：

:A series of new quinoline derivatives was designed, synthesized and evaluated for their antiproliferative activity. The results demonstrated that compounds 11p, 11s, 11v, 11x and 11y exhibited potent antiproliferative activity with IC50 value of lower than 10 μM against seven human tumor cell lines, and N-(3-methoxyphenyl)-7- (3-phenylpropoxy)quinolin-4-amine 11x was found to be the most potent antiproliferative agent against HCT-116, RKO, A2780 and Hela cell lines with an IC50 value of 2.56, 3.67, 3.46 and 2.71 μM, respectively. The antitumor efficacy of the representative compound 11x in mice was also evaluated, and the results showed that compound 11x effectively inhibited tumor growth and decreased tumor weight in animal models. Further investigation on mechanism of action indicated that compound 11x could inhibit colorectal cancer growth through ATG5-depenent autophagy pathway. Therefore, these quinoline derivatives are a new class of molecules that have the potential to be developed as new antitumor drugs.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Su T,Zhu J,Sun R,Zhang H,Huang Q,Zhang X,Du R,Qiu L,Cao R

doi

10.1016/j.ejmech.2019.05.088

subject

Has Abstract

pub_date

2019-09-15 00:00:00

pages

154-167

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(19)30512-4

journal_volume

178

pub_type

杂志文章

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