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Novel cross-link breaker based on zwitterion structure: synthesis, structure and druggability studies.

Abstract：

:It has been universally acknowledged that the increase in cardiac and vascular stiffness is due to the formation of advanced glycosylation end-products (AGEs). Research on the stable form of 3-(carboxymethyl)-4-methylthiazol bromide sodium salt (C6H7BrNNaO2S) showed that it had a notable effect on breaking the AGEs. Two compounds with novel structures, zwitterionic 3-(carboxymethyl)-4-methylthiazol (C6H7O2NS) and a dipolymer (C12H15O4N2S2Br) complex, were obtained. When compared with the forms of sodium salt and dipolymer, zwitterion had an obvious advantage in stability, solubility, synthesis and pH, which made the zwitterion a promising drug. The structure of sodium salt, dipolymer and zwitterion was comparatively analyzed by such methods as single crystal X-ray diffraction, ESI-MS, 1H NMR, FT-IR and in situ IR.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Cao S,Zhou XB,Zhang H,Li S,Zhong W

doi

10.1016/j.ejmech.2013.07.033

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

89-95

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00481-9

journal_volume

68

pub_type

杂志文章

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