当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.

Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.

Abstract：

:The present study aims at design and synthesis of newer gamma-aminobutyric acid (GABA) derivatives with the combination of thiosemicarbazone and GABA pharmacophores in order to develop newer anticonvulsants. The reported compounds were designed as bioisosteric analogues of GABA semicarbazones. The structures of the synthesized compounds were confirmed by the use of their spectral data besides elemental analysis. Initial anticonvulsant screening was performed using intraperitoneal (i.p.) maximal electroshock-induced seizure (MES), subcutaneous pentylenetetrazole (scPTZ), subcutaneous strychnine (scSTY), and subcutaneous picrotoxin (scPIC)-induced seizure threshold tests. A model involving 22-day old rat pups was also employed to further screen the effects of the test compounds against hyperthermia-induced febrile seizures. Only compounds 1 and 11 were found to be active in the MES test. Most of the compounds were found to be effective in the scPIC and febrile seizure models and very few compounds showed protection in scPTZ and scSTY models. This is the first report on these new GABA derivatives effective in the treatment of febrile seizures.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ragavendran JV,Sriram D,Kotapati S,Stables J,Yogeeswari P

doi

10.1016/j.ejmech.2008.01.036

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

2650-5

issue

12

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00067-6

journal_volume

43

pub_type

杂志文章

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