Abstract:
:Polyether ionophore antibiotics (ionophores) represent a large group of more than 120 lipid-soluble compounds that are widely used in veterinary medicine because of their significant antimicrobial activity. In addition to the industrial use of ionophores, some of them effectively and selectively inhibit properties of different cancer cells and enhance the antitumor effects of chemo- and/or radiotherapy. Salinomycin (SAL) is particularly interesting in this regard as it shows potent activity against various types of cancer cells, including those that display multi-drug resistance, and cancer stem cells. Therefore, a very interesting direction of research is chemical modification of SAL which may lead to obtaining analogs that are characterized by better biological activity and lower toxicity than those of the starting compound. This review article is focused on the possible role of both SAL-based drug delivery systems and SAL derivatives in future cancer therapy.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Antoszczak Mdoi
10.1016/j.ejmech.2019.01.034subject
Has Abstractpub_date
2019-03-15 00:00:00pages
48-64eissn
0223-5234issn
1768-3254pii
S0223-5234(19)30044-3journal_volume
166pub_type
杂志文章,评审abstract::Leukotrienes (LTs) and prostaglandin (PG)E2 are enzymatically produced from arachidonic acid and represent highly bioactive lipid mediators with pro-inflammatory functions. Here, we report on novel multi-target inhibitors that potently and dually interfere with 5-lipoxygenase-activating protein (FLAP) and microsomal p...
journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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journal_title:European journal of medicinal chemistry
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