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Synthesis and cytotoxicity assay of four ganglioside GM3 analogues.

Abstract：

:A concise and efficient synthetic route for preparation of four ganglioside GM3 analogues was described. The key step is a highly regioselective and stereoselective α-sialylation from a suitably protected glycoside acceptor with a sialyl xanthate to provide the sialo-oligosaccharide in good yield. The cytotoxic properties of the synthetic gangliosides were evaluated against normal human keratinocytes and human HCT116 and K562 cancer cells. Two of them exhibited good antiproliferative activity and displayed a better cytotoxicity against cancer cell than HaCaT normal cell.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Qu H,Liu JM,Wdzieczak-Bakala J,Lu D,He X,Sun W,Sollogoub M,Zhang Y

doi

10.1016/j.ejmech.2014.01.054

subject

Has Abstract

pub_date

2014-03-21 00:00:00

pages

247-57

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00100-7

journal_volume

75

pub_type

杂志文章

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