Abstract:
:A series of 7H-pyrrolo[2,3-d]pyrimidine derivatives possessing a dimethylphosphine oxide moiety were designed, synthesized and evaluated as novel Focal adhesion kinase (FAK) inhibitors. Most compounds potently suppressed the enzymatic activities of FAK, with IC50 values in the 10-8-10-9 M range, and potently inhibited the proliferation of breast (MDA-MB-231) and lung (A549) cancer cell lines. The representative compound 25b exhibited potent enzyme inhibition (IC50 = 5.4 nM) and good selectivity when tested on a panel of 26 kinases. 25b exhibited antiproliferative activity against A549 cells (IC50 = 3.2 μM) and relatively less cytotoxicity to a normal human cell line HK2. Compound 25b also induced apoptosis and suppressed the migration of A549 cells in a concentration-dependent manner. Further profiling of compound 25b revealed it had good metabolic stability in mouse, rat and human liver microsomes in vitro and showed weak inhibitory activity against various subtypes of human cytochrome P450. The docking study of compound 25b was performed to elucidate its possible binding modes and to provide a structural basis for further structure-guided design of FAK inhibitors.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Wang R,Chen Y,Zhao X,Yu S,Yang B,Wu T,Guo J,Hao C,Zhao D,Cheng Mdoi
10.1016/j.ejmech.2019.111716subject
Has Abstractpub_date
2019-12-01 00:00:00pages
111716eissn
0223-5234issn
1768-3254pii
S0223-5234(19)30868-2journal_volume
183pub_type
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