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Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.

Abstract：

:Two series of pharmacophoric hybrids of phthalimide-GABA-anilides/hydrazones were designed and synthesized and evaluated for their anticonvulsant and neurotoxic properties. The structures of the synthesized compounds were confirmed by the use of their spectral data besides elemental analysis. Initial anticonvulsant screening was performed using intraperitoneal (i.p.) maximal electroshock-induced seizure (MES), subcutaneous pentylenetetrazole (scPTZ), subcutaneous strychnine (scSTY), and intraperitoneal picrotoxin (ipPIC)-induced seizure threshold tests. All of the compounds were ineffective in the MES test. Most of the compounds were found to be effective in the scSTY and ipPIC models and very few compounds showed protection in the scPTZ model.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ragavendran JV,Sriram D,Patel SK,Reddy IV,Bharathwajan N,Stables J,Yogeeswari P

doi

10.1016/j.ejmech.2006.08.010

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

146-51

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(06)00290-X

journal_volume

42

pub_type

杂志文章

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