Abstract:
:Inflammation comprises the reaction of the body to injury, in which a series of changes of the terminal vascular bed, blood, and connective tissue tends to eliminate the injurious agent and to repair the damaged tissue. It is a complex process, which involves the release of diverse regulatory mediators. The current anti-inflammatory agents are challenged by multiple side effects and thus, new effective therapies are highly needed. The aim of this review is to summarize the described microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors or transcriptional suppressors from medicinal plants, which could be an ideal approach in the management of inflammatory disorders, but need further clinical trials in order to be ultimately validated.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Khan H,Rengasamy KRR,Pervaiz A,Nabavi SM,Atanasov AG,Kamal MAdoi
10.1016/j.ejmech.2017.12.059subject
Has Abstractpub_date
2018-06-10 00:00:00pages
2-28eissn
0223-5234issn
1768-3254pii
S0223-5234(17)31090-5journal_volume
153pub_type
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