Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication.

Abstract:

:Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (

journal_name

Eur J Med Chem

authors

Li YQ,Li ZL,Zhao WJ,Wen RX,Meng QW,Zeng Y

doi

10.1016/j.ejmech.2006.03.024

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1084-9

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(06)00143-7

journal_volume

41

pub_type

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