Abstract：
:Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases, around one-third of the world's population harbor a latent infection by Mycobacterium tuberculosis (MTB), and 5-10% eventually develop an active TB. The emergency of MTB new virulent forms as well as the co-infection between MTB and HIV alarming the serious problem in TB control and demanding the need for new drugs more potent than earlier with safe ADME profile. Fluoroquinolones are emerged as a large family of synthetic broad spectrum antibiotics, and some of them were recommended as the second-line agents for the treatment of TB mainly in cases involving resistance or intolerance to first-line anti-TB therapy by WHO. Numerous of FQs derivatives have been synthesized for seeking for new anti-TB agents, and some of them exhibited promising potency. This review aims to summarize the recent advances made towards the discovery of FQs derivatives as anti-TB agents and the structure-activity relationship of these derivatives.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Fan YL,Wu JB,Cheng XW,Zhang FZ,Feng LSdoi
10.1016/j.ejmech.2018.01.080subject
Has Abstractpub_date
2018-02-25 00:00:00pages
554-563eissn
0223-5234issn
1768-3254pii
S0223-5234(18)30099-0journal_volume
146pub_type
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