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Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents.

Abstract：

:Five series of thiourea derivatives bearing benzothiazole moiety (20 compounds) were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds 1b, 2b, 3b, 4b and 5b exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. In preliminary MTT cytotoxicity studies, the thiourea derivatives (2d, 5c and 5d) were found most potent. In MCF-7 and HeLa cells, the IC(50) values were observed in the range of 18-26 microM and 38-46 microM, respectively.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Saeed S,Rashid N,Jones PG,Ali M,Hussain R

doi

10.1016/j.ejmech.2009.12.016

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1323-31

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00642-4

journal_volume

45

pub_type

杂志文章

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