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Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives.

Abstract：

:Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy. Examples of metal compounds and chelating agents currently in clinical use, clinical trials or preclinical development are highlighted.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Lazarević T,Rilak A,Bugarčić ŽD

doi

10.1016/j.ejmech.2017.04.007

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

8-31

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(17)30262-3

journal_volume

142

pub_type

杂志文章,评审

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