Abstract:
:Four (99m)Tc-labeled fatty acid analogs, 1b, 2b, 3b, 4b were synthesized by a double ligand transfer reaction and theirs potential were investigated. The radiochemical yield of the radiotracers was from 11.7% to 30.3% (no decay corrected). Those compounds were found to be chemically stable when incubated in SD rat serum for 3 h at 37 °C. The biodistribution studies in mice showed that high radioactivity accumulated of Tc-99m complexes were observed, followed by moderate clearance from the heart. The maximum heart/blood ratio was 5.7 at 15 min postinjection of 1b. Metabolite analysis showed 1b was not metabolized by β-oxidation in the heart. These results suggest that 1b may be a promising radiotracer for evaluation of myocardial viability.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Zeng H,Zhang Hdoi
10.1016/j.ejmech.2013.11.015subject
Has Abstractpub_date
2014-01-24 00:00:00pages
10-7eissn
0223-5234issn
1768-3254pii
S0223-5234(13)00749-6journal_volume
72pub_type
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