Synthesis and biological evaluation of water-soluble organogermanium.

Abstract:

:Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study.

journal_name

Eur J Med Chem

authors

Choi S,Oh C,Han J,Park J,Choi JH,Min NY,Lee KH,Park AJ,Kim YJ,Jang SJ,Lee DH,Ham SW

doi

10.1016/j.ejmech.2009.12.069

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1654-6

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00037-1

journal_volume

45

pub_type

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