Abstract：
:Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Choi S,Oh C,Han J,Park J,Choi JH,Min NY,Lee KH,Park AJ,Kim YJ,Jang SJ,Lee DH,Ham SWdoi
10.1016/j.ejmech.2009.12.069subject
Has Abstractpub_date
2010-04-01 00:00:00pages
1654-6issue
4eissn
0223-5234issn
1768-3254pii
S0223-5234(10)00037-1journal_volume
45pub_type
杂志文章abstract：:The synthesis and anticonvulsant properties of new N-diethylmalonyl derivatives of nifedipine and other isosteric analogues (7a-7n) were described. Anticonvulsant screening was performed by subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock (MES) induced seizures tests. Majority of the compounds were eff...
journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
pub_type： 杂志文章,评审
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
pub_type： 杂志文章,评审
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1016/j.ejmech.2011.10.027
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journal_title：European journal of medicinal chemistry
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doi：10.1016/j.ejmech.2006.03.007
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journal_title：European journal of medicinal chemistry
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doi：10.1016/j.ejmech.2005.01.006
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更新日期：2004-01-01 00:00:00
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
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journal_title：European journal of medicinal chemistry
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abstract：:There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain and other indications. In continuation of our ongoing program aiming for the development of new small molecule cannabinoid ligands, we have synthesized a novel series of carbazole and γ-carboline derivatives....
journal_title：European journal of medicinal chemistry
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