Synthesis and biological evaluation of water-soluble organogermanium.


:Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study.


Eur J Med Chem


Choi S,Oh C,Han J,Park J,Choi JH,Min NY,Lee KH,Park AJ,Kim YJ,Jang SJ,Lee DH,Ham SW




Has Abstract


2010-04-01 00:00:00














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  • 4-Phenyl quinoline derivatives as potential serotonin receptor ligands with antiproliferative activity.

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    authors: Joshi PV,Sayed AA,RaviKumar A,Puranik VG,Zinjarde SS

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    authors: Kini SG,Bhat AR,Bryant B,Williamson JS,Dayan FE

    更新日期:2009-02-01 00:00:00

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Wang ZJ,Gao Y,Hou YL,Zhang C,Yu SJ,Bian Q,Li ZM,Zhao WG

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章,评审


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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Ashraf Z,Rafiq M,Seo SY,Kwon KS,Babar MM,Zaidi NU

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    pub_type: 杂志文章


    authors: Teixeira C,Serradji N,Maurel F,Barbault F

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    authors: Bellia F,Amorini AM,La Mendola D,Vecchio G,Tavazzi B,Giardina B,Di Pietro V,Lazzarino G,Rizzarelli E

    更新日期:2008-02-01 00:00:00

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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

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    authors: Li YQ,Li ZL,Zhao WJ,Wen RX,Meng QW,Zeng Y

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    journal_title:European journal of medicinal chemistry

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    authors: Adrian Meredith J,Wallberg H,Vrang L,Oscarson S,Parkes K,Hallberg A,Samuelsson B

    更新日期:2010-01-01 00:00:00

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    authors: Kahnt M,Heller L,Grabandt P,Al-Harrasi A,Csuk R

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    journal_title:European journal of medicinal chemistry

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    pub_type: 杂志文章


    authors: Chen CY,Lin CM,Lin HC,Huang CF,Lee CY,Si Tou TC,Hung CC,Chang CS

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Li D,Cai H,Jiang B,Liu G,Wang Y,Wang L,Yao H,Wu X,Sun Y,Xu J

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Ahmed FF,Abd El-Hafeez AA,Abbas SH,Abdelhamid D,Abdel-Aziz M

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章,评审


    authors: Venepally V,Reddy Jala RC

    更新日期:2017-12-01 00:00:00

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Liu Q,Su RC,Yi WJ,Zheng LT,Lu SS,Zhao ZG

    更新日期:2017-03-31 00:00:00

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Gao F,Ye L,Wang Y,Kong F,Zhao S,Xiao J,Huang G

    更新日期:2019-12-01 00:00:00

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    abstract::A series of fused and non fused 1,2,4-triazoles with (2,4-dichlorophenoxy) moiety are prepared utilizing 3-((2,4-dichlorophenoxy)methyl)-4-amino-4H-1,2,4-triazole-5-thiol (3). The latter on reaction with carboxylic acids, ethylchloroformate, ethylcyanoacetate and sodium nitrite gives five membered fused triazole deriv...

    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: El Shehry MF,Abu-Hashem AA,El-Telbani EM

    更新日期:2010-05-01 00:00:00