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Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones.

Abstract：

:In a wide search program towards new and efficient antimicrobial agents, a series of 40 substituted chalcones have been synthesized and tested for their in vitro antibacterial and antifungal activities. The structures of these compounds have been investigated by nuclear magnetic resonance spectroscopy and mass spectrometry. Among the (E)-4-aminoalkylthiochalcones and (E)-4-aminoalkoxychalcones tested, compounds 7, 10, 11, 30 and 31 have exhibited good antibacterial property against Staphylococcus aureus, Enterococcus faecalis and Bacillus subtilis.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Nowakowska Z,Kedzia B,Schroeder G

doi

10.1016/j.ejmech.2007.05.006

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

707-13

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00226-7

journal_volume

43

pub_type

杂志文章

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