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Present status of quinoxaline motifs: excellent pathfinders in therapeutic medicine.

Abstract：

:Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide biological properties and diverse therapeutic applications in medicinal research. They are complementary in shapes and charges to numerous biomolecules they interact with, thereby resulting in increased binding affinity. The pharmacokinetic properties of drugs bearing quinoxaline cores have shown them to be relatively easy to administer either as intramuscular solutions, oral capsules or rectal suppositories. This work deals with recent advances in the synthesis and pharmacological diversities of quinoxaline motifs which might pave ways for novel drugs development.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ajani OO

doi

10.1016/j.ejmech.2014.08.034

subject

Has Abstract

pub_date

2014-10-06 00:00:00

pages

688-715

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00769-7

journal_volume

85

pub_type

杂志文章,评审

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