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Recent developments of quinolone-based derivatives and their activities against Escherichia coli.

Abstract：

:Escherichia coli (E. coli) is the most common pathogen in both hospital and community settings, and is capable of causing infections that can lead to serious consequences. Quinolones, one of the most common antibiotics in clinical use, are effective weapons to treat E. coli infections. However, the resistance of E. coli to quinolones develops rapidly and spreads widely. Thus, it has become increasingly urgent to enhance the potency of quinolones against both drug-susceptible and drug-resistant E. coli. This review aims to summarize the recent developments of quinolone derivatives with potential activity against E. coli, and to discuss the structure-activity relationship for further rationale design of this kind of derivatives.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Gao F,Wang P,Yang H,Miao Q,Ma L,Lu G

doi

10.1016/j.ejmech.2018.08.095

subject

Has Abstract

pub_date

2018-09-05 00:00:00

pages

1223-1248

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(18)30767-0

journal_volume

157

pub_type

杂志文章,评审

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