当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > 2,2'-bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced Peripheral blood mononuclear cells.

2,2'-bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced Peripheral blood mononuclear cells.

Abstract：

:2,2'-bipyridyl based copper complex I: [CuC24H22N6O10] at 10 nM and complex Ia: [Cu2C32H43N8O3](PF6)4 at 7 nM exhibited 50% inhibition of lymphocyte proliferation and less than 20% cytotoxicity in peripheral blood mononuclear cells (PBMCs). Further, pro-inflammatory cytokines such as TNF-alpha and IL-1beta and pro-inflammatory mediator such as Nitric Oxide (NO) besides inducible Nitric Oxide Synthase (iNOS) were inhibited by the copper complexes. They also down regulated the expression of cyclooxegenase-2 (COX-2), yet another mediator of inflammation. Immunoblot analysis revealed the inhibitory effect of these complexes on phosphorylated forms protein kinases (MAPKs) such as ERK1/2, JNK, and p38 in mitogen induced PBMCs.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Rupesh KR,Priya AM,Sundarakrishnan B,Venkatesan R,Lakshmi BS,Jayachandran S

doi

10.1016/j.ejmech.2010.01.041

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

2141-6

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00086-3

journal_volume

45

pub_type

杂志文章

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