当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

Abstract：

:A series of 1H,3H-thiazolo[4,3-b]quinazolines (2a-i) were synthesized and evaluated for their in vitro antitumour activity against ca. 60 human tumour cell lines. They exhibited moderate (2c, 2d, 2f and 2g) to strong (2a, 2b, 2e, 2h and 2i) cell-growth inhibition at a concentration of 10(-4) M, but weak activity at lower concentrations. Only 1-(2,6-dichlorophenyl)-1H,3H-thiazolo[4,3-b]quinazoline (2h) possesses a significant growth inhibitory activity on 22 cell lines at a concentration of 10(-5) M.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Grasso S,Micale N,Monforte AM,Monforte P,Polimeni S,Zappalà M

doi

10.1016/s0223-5234(00)01195-8

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1115-9

issue

12

eissn

0223-5234

issn

1768-3254

pii

S0223523400011958

journal_volume

35

pub_type

杂志文章

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