Abstract:
:A series of novel pleuromutilin derivatives with substituted 6-methylpyrimidine moieties was designed, synthesized, and evaluated for their antibacterial activities. Most of the tested compounds exhibited potent antibacterial activities against Staphylococcus aureus ATCC 25923 (S. aureus-25923), methicillin-resistant Staphylococcus epidermidis ATCC 51625 (MRSE-51625), methicillin-resistant Staphylococcus aureus BNCC 337371 (MRSA-337371), Streptococcus dysgalactiae (S. dysgalactiae) and Streptococcus agalactiae (S. agalactiae). Compounds 5c and 5g were the most active and displayed bacteriostatic activities against MRSA. In vivo mouse systemic infection experiment showed that 5c significantly improved the survival rate of mice (ED50 = 18.02 mg/kg), reduced the bacterial load and alleviated the pathological changes in the lungs of the affected mice.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Fan Y,Liu Y,Wang H,Shi T,Cheng F,Hao B,Yi Y,Shang Rdoi
10.1016/j.ejmech.2020.112735subject
Has Abstractpub_date
2020-12-01 00:00:00pages
112735eissn
0223-5234issn
1768-3254pii
S0223-5234(20)30707-8journal_volume
207pub_type
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