当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Urea/thiourea derivatives of quinazolinone-lysine conjugates: synthesis and structure-activity relationships of a new series of antimicrobials.

Urea/thiourea derivatives of quinazolinone-lysine conjugates: synthesis and structure-activity relationships of a new series of antimicrobials.

Abstract：

:Synthesis of a series of urea/thiourea/acetamide/sulphonamide derivatives of quinazolinones conjugated lysine has been reported. Structures of the products have been determined by standard spectroscopical studies. All the compounds have been screened for their antibacterial studies and structure-activity relationship has been developed. The activity profile revealed that the compounds containing urea and thiourea functionalities along with fluoro group have exerted a highly potent activity. Thus, the title compounds represent a novel class of potent antimicrobial agents.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Suresha GP,Suhas R,Kapfo W,Gowda DC

doi

10.1016/j.ejmech.2011.03.041

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

2530-40

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00256-X

journal_volume

46

pub_type

杂志文章

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