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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: part II.

Abstract：

:A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Yang JS,Song D,Ko WJ,Kim B,Kim BK,Park SK,Won M,Lee K,Lee K,Kim HM,Han G

doi

10.1016/j.ejmech.2012.12.063

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

621-8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00122-0

journal_volume

63

pub_type

杂志文章

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