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Microwave assisted synthesis of unsaturated jasmone heterocyclic analogues as new fragrant substances.

Abstract：

:Taking the rising interest in jasmone structure based fragrant compounds into account it has been decided to take up an attempt to synthesize the new heterocyclic derivatives of this 2,3-disubstituted cyclopentenone, which could be characterized by the ability of interaction with the same receptors with which jasmone affects. Obtained structures of unsaturated heterocyclic derivatives are based on pyrrolidinone, oxazolidinone, pyrazolidinone, pyrazolone and thiazolidinone systems with 2-double or 2-triple unsaturated five-carbon side chain. The rapid, highly yielding and ecofriendly microwave assisted organic syntheses (MAOS) have been used to obtain compounds mentioned above. Odor evaluation and relationships between their structure and osmic properties for all synthesized fragrant compounds have been studied. It has been shown that the majority of the obtained compounds have exhibited interesting, very intensive and fixative fragrant properties.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Pawełczyk A,Zaprutko L

doi

10.1016/j.ejmech.2008.07.028

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

3032-9

issue

7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00357-7

journal_volume

44

pub_type

杂志文章

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