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Design and synthesis of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents.

Abstract：

:Type 2 diabetes (T2D) is a lifestyle disease affecting millions of people worldwide. Various therapies are available for the management of T2D and dipeptidyl peptidase-IV (DPP-IV) inhibition has emerged as a promising therapy for the treatment of type 2 diabetes (T2D). Here we report design, synthesis and in vitro efficacy of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents. Amongst all the compounds synthesized in this series, 9a, is the most potent (IC50 = 41.17 nM).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Sharma R,Soman SS

doi

10.1016/j.ejmech.2014.11.041

subject

Has Abstract

pub_date

2015-01-27 00:00:00

pages

342-50

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)01073-3

journal_volume

90

pub_type

杂志文章

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