当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer.

Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer.

Abstract：

:While photodynamic therapy is known for significant advantages over conventional cancer therapies, its dependence on light has limited it to treating tumors on or just under the skin or on the outer lining of organs/cavities. Herein, we have developed a single-molecule photosensitizer capable of intracellular self-activation and with potential tumor-selectivity due to a chemiluminescent reaction involving only a cancer marker. Thus, the photosensitizer is directly chemiexcited to a triplet excited state capable of generating singlet oxygen, without requiring either a light source or any catalyst/co-factor. Cytotoxicity assays involving the photosensitizer show significant toxicity toward tumor cells, even better than reference drugs, while not inducing toxicity toward normal cells. This work provides a proof-of-concept for a novel type of photosensitizer that eliminates the current restrictions that photodynamic therapy presents regarding tumor size and localization.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Pinto da Silva L,Núnez-Montenegro A,Magalhães CM,Ferreira PJO,Duarte D,González-Berdullas P,Rodríguez-Borges JE,Vale N,Esteves da Silva JCG

doi

10.1016/j.ejmech.2019.111683

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

111683

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(19)30833-5

journal_volume

183

pub_type

杂志文章

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