Abstract:
:A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities. Some of the newly synthesized compounds were found to possess antiproliferative properties, whereas no anti-HIV activity was seen; the most active of the series was the derivative 2i, which exhibited tumour growth inhibition activity against all cell lines displaying GI50 values between 1.63 and 26.5 microM. The title compounds were generally ineffective against Gram-positive and Gram-negative bacteria, while showed a moderate antifungal activity against C. albicans and A. fumigatus.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Savini L,Chiasserini L,Travagli V,Pellerano C,Novellino E,Cosentino S,Pisano MBdoi
10.1016/j.ejmech.2003.09.012subject
Has Abstractpub_date
2004-02-01 00:00:00pages
113-22issue
2eissn
0223-5234issn
1768-3254pii
S0223523403002162journal_volume
39pub_type
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