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Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.

Abstract：

:The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Pinto A,Conti P,Grazioso G,Tamborini L,Madsen U,Nielsen B,De Micheli C

doi

10.1016/j.ejmech.2010.12.020

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

787-93

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00876-7

journal_volume

46

pub_type

杂志文章

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