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Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells.

Abstract：

:A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alpha- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Landi M,Catelani G,D'Andrea F,Ghidini E,Amari G,Paola P,Bianchi N,Gambari R

doi

10.1016/j.ejmech.2008.05.001

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

745-54

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00264-X

journal_volume

44

pub_type

杂志文章

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